Research Paper Volume 16, Issue 9 pp 8019—8030
AURKB promotes colorectal cancer progression by triggering the phosphorylation of histone H3 at serine 10 to activate CCNE1 expression
Figure 1. AURKB was identified as a potent oncogene in CRC. (A) Expression profile of AURKB in GEO dataset GSE74602. (B) Matched comparison of AURKB expression between tumor and non-tumor tissues in GSE74602 dataset. (C) The mRNA expression between tumor and normal tissues was compared between TCGA Colon adenocarcinoma (COAD) and Rectum adenocarcinoma (READ) databases. (D) Representative images of AURKB staining in CRC tumor tissues and normal colon and rectum tissues were obtained from HPA database (https://www.proteinatlas.org/). (E) The correlation between AURKB and Ki-67 expression in CRC tissues was obtained from TCGA database using cBioPortal website (https://www.cbioportal.org/).