Research Paper Volume 16, Issue 18 pp 12498—12509
SHP2 mediates STAT3/STAT6 signaling pathway in TAM to inhibit proliferation and metastasis of lung adenocarcinoma
Figure 7. GM-CSF secreted by lung adenocarcinoma cells can stimulate the activation of STAT3/STAT6 signaling pathway in TAM, and promote the cathepsin secretion and M2 polarization, thus promoting the proliferation and migration of lung adenocarcinoma. SHP2 can inhibit the development of lung adenocarcinoma by suppressing STAT3.