Research Paper Volume 16, Issue 9 pp 7946—7960

Trigeminal nerve electrical stimulation attenuates early traumatic brain injury through the TLR4/NF-κB/NLRP3 signaling pathway mediated by orexin-A/OX1R system

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Figure 2. Trigeminal nerve electrical stimulation (TNS) mitigates neurological deficits and cerebral edema. (A, B) Neurological function was analyzed and modified by neurological severity scores (mNSS) and loss of righting reflex test (LORR) after traumatic brain injury (TBI). (C) The brain water content of each group was detected 24 h post-TBI (*P < 0.05, **P < 0.01, ***P < 0.001).