Research Paper Volume 16, Issue 9 pp 7915—7927
IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis
Figure 8. In shoulder arthritis, IL21 can inhibit the expression of miR-361-5p in chondrocytes thereby mediating MAP3K9 in chondrocytes to promote the activation of the ERK1/2/NF-κB signaling pathway, further inhibiting the expression and secretion of MMPs and aggravates the progression of shoulder arthritis.