Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules

Wei Li; Dayong Du; Yan Huang; Cui Xu; Yang Liu; Xiaohong Wu; Jie Yang; Zhipeng Liu; Jianxin Ma; Chaoji Huangfu

doi:doi:10.18632/aging.205792

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Research Paper Volume 16, Issue 9 pp 7902—7914

Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules

Figure 5. Target molecules were validated with transcriptome sequencing and western blotting. (A) PCA analysis revealed that samples within the same group clustered together. (B, C) GO and KEGG analysis was performed to find potential targeting genes and pathways. (D) Top 20 differential genes between the two groups were presented. (E, F) The expression of ITGB4, ITGA3, LAMB3, and LAMA5 was detected with western blotting and RT-PCR. ^**p < 0.01 compared with control group, ^***p < 0.001 compared with control group.