Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules

Wei Li; Dayong Du; Yan Huang; Cui Xu; Yang Liu; Xiaohong Wu; Jie Yang; Zhipeng Liu; Jianxin Ma; Chaoji Huangfu

doi:doi:10.18632/aging.205792

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Research Paper Volume 16, Issue 9 pp 7902—7914

Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules

Figure 3. BMSCs-GSSM-gel accelerated wound healing. (A, B) BMSCs-GSSM-gel greatly improved skin wound healing in rabbit model (6 animals in each group). (C, D) BMSCs-GSSM-gel greatly improved skin wound healing in mouse model (9 animals in each group). (E) HE staining was performed to investigate skin histological changes. (F, G) Collagen deposition was evaluated with Masson’s trichrome and Sirius red staining. ^*p < 0.05 compared with control group, ^**p < 0.01 compared with control group, ^***p < 0.001 compared with control group.