Review Volume 16, Issue 8 pp 7487—7504

Figure 4. Three greatly important metabolic pathways in digestive system tumors. The metabolic process of metabolites and the proteins involved in their regulation. Differentially expressed metabolites (red), unchanged metabolites (grey) regulated proteins (yellow), metabolic pathway names (blue). Abbreviations: acnA: aconitate hydratase; AGXT: alanine-glyoxylate transaminase/serine-glyoxylate transaminase and serine-pyruvate transaminase; CS: citrate synthase; CYP11A: cholesterol monooxygenase; CYP17A: steroid 17alpha-monooxygenase/17alpha-hydroxyprogesterone deacetylase; CYP19A: aromatase; CYP11B1: steroid 11beta-monooxygenase; CYP11B2: steroid 11beta-monooxygenase/corticosterone 18-monooxygenase; CYP21A: steroid 21-monooxygenase; GGAT: glutamate--glyoxylate aminotransferase; GLU: glutamate synthase; GLUL: glutamine synthetase; GLUT1: glucose transporter 1; glyA: glycine hydroxymethyltransferase; GOT: aspartate aminotransferase; HAO: (S)-2-hydroxy-acid oxidase; HSD17B2: corticosteroid 11-beta-dehydrogenase isozyme 2; HSD17B2: 17beta-estradiol 17-dehydrogenase/3alpha(17beta)-hydroxysteroid dehydrogenase; HSD3B: 3beta-hydroxy-Delta5-steroid dehydrogenase; IL4I1: L-amino-acid oxidase; ICL: isocitrate lyase; mdh: malate dehydrogenase; PAT: bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; PC: pyruvate carboxylase; PGP: phosphoglycolate phosphatase; pheA2: prephenate dehydratase; SRD5A1: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; tyrA2: prephenate dehydrogenase; tyrC: cyclohexadieny/prephenate dehydrogenase.