Research Paper Volume 16, Issue 9 pp 7704—7732
Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transition
Figure 5. Cell communication in different myeloid cell subtypes. (A, B) Depiction of cell communication networks among distinct myeloid cell subtypes in primary (A) and liver metastasis (B) colorectal cancer tissues. (C) Utilization of bubble plots to visualize the intensity of cell communication outgoing and incoming signals. (D) Comparative analysis of signal strengths emanating from different secreted factors. (E, F) Heatmaps illustrating the intensity of various outgoing (E) and incoming (F) signal patterns within myeloid cell subtypes. (G) Presentation of bubble plots showcasing the signal strength of ligand-receptor pairs during interactions between malignant cells and tumor stem cells with myeloid cell subtypes. (H) Display of bubble plots illustrating the signal strength of ligand-receptor pairs during interactions of myeloid cell subtypes with malignant cells and tumor stem cells.