Research Paper Volume 16, Issue 9 pp 7704—7732

Figure 1. Cell annotations and features of colorectal cancer tissues from primary and liver metastasis. (A, B) UMAP-based dimensionality reduction clustering plots depict the annotation results of main cell types in primary (A) and liver metastasis (B) colorectal cancer tissues, along with further subannotations for epithelial cells, myeloid cells, and NK/T cells. (C, D) Bubble plots illustrate the expression levels of the top 3 markers in main cell types of primary (C) and liver metastasis (D) colorectal cancer tissues. (E, F) UMAP-based dimensionality reduction is employed to illustrate the density features of the top 1 marker in main cell types of primary (E) and liver metastasis (F) colorectal cancer tissues. (G) A proportion plot displays the distribution of primary cell types across 16 different primary colorectal cancer tissues. (H) A heatmap presents the expression levels of the top 50 differentially expressed genes in the main cell types of primary colorectal cancer tissues. (I) A proportion plot depicts the distribution of main cell types in 16 different liver metastasis colorectal cancer tissues. (J) A heatmap displays the expression levels of the top 50 differentially expressed genes in the main cell types of liver metastasis colorectal cancer tissues.