Research Paper Volume 16, Issue 8 pp 6673—6693

Figure 3. Comprehensive transcriptional analysis of UV-A- and IR-induced senescent human corneal endothelial cells. (A) Principal component score analysis of UV-A- and IR-induced senescent and non-senescent (control) hCEnCs (n=4, respectively). (B) Venn diagram analysis of differentially expressed genes upregulated (left) and downregulated (right) in UV-A- and IR-induced senescent hCEnCs compared to control (fold change ≥ 2, q-value ≤ 0.05). (C) Volcano plot comparing UV-A-induced senescent hCEnCs and control, and (D) Volcano plot comparing IR-induced senescent hCEnCs and control, show Q-values (−log10) vs. fold change of (log2) UV-A- or IR-induced senescent hCEnCs and control. Blue, downregulated genes; red, upregulated genes; and black, no significant change (fold change ≥ 2, q-value ≤ 0.05).