Figure 4. Feature biomarkers selection via machine language algorithms. (A) Key LAGs screening by LASSO analysis. (B) RF analysis of key DE-LAGs, the filter condition for screening feature variates was set at: importance > 3. (C) SVM-RFE algorithm for selecting the feature DE-LAGs. (D) Venn network plot showed the three diagnostic feature biomarkers based on LASSO, SVM-RF and RF algorithm.