Figure 7. Patients with high TLS were sensitive to immunotherapy. (A) Comparing the TLS between responders and non-responders in the GSE194040 cohort (BRCA). (B) Heatmap showing the immune checkpoints expression between TLS-high and low groups in the GSE194040 cohort. (C) Bar plot showing the fractions of CR and NR patients in the TLS-high and low groups in the GSE194040 cohort. (D) Comparing the TLS between responders and non-responders in the PRJEB23709 cohort (Melanoma). (E) Heatmap showing the immune checkpoints expression between TLS-high and low groups in the PRJEB23709 cohort. (F) Bar plot showing the fractions of CR and NR patients in the TLS-high and low groups in the PRJEB23709 cohort. Wilcoxon rank-sum test was performed to measure the difference between two groups.