Research Paper Volume 16, Issue 3 pp 2989—3006
Minocycline alleviates LPS-induced cognitive dysfunction in mice by inhibiting the NLRP3/caspase-1 pathway
Figure 3. Minocycline inhibited LPS-induced microglial activation in the mice hippocampus. (A, B) An IHC staining assay was performed to detect the Iba-1 level in hippocampal tissues. (C, D) The expression level of Iba-1 was elucidated by a Western blot assay. Data were presented as mean ± SD, n = 5–6 mice per group; *P < 0.05, **P < 0.01, ***P < 0.001 vs. Control group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. LPS group.