Integrative analysis of single-cell and bulk RNA-sequencing data revealed disulfidptosis genes-based molecular subtypes and a prognostic signature in lung adenocarcinoma

Haixia Wang; Xuemei Zhu; Fangchao Zhao; Pengfei Guo; Jing Li; Jingfang Du; Guoyong Shan; Yishuai Li; Juan Li

doi:doi:10.18632/aging.205509

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Research Paper Volume 16, Issue 3 pp 2753—2773

Integrative analysis of single-cell and bulk RNA-sequencing data revealed disulfidptosis genes-based molecular subtypes and a prognostic signature in lung adenocarcinoma

Figure 6. Associations between the DRG score and TMB as well as ICGs. (A, B) A comparative analysis of mutational profiles in two risk groups of LUAD. (C) Correlations between TMB and the DRG score within various gene clusters. (D) Disparities in TMB score among high-risk and low-risk groups. (E) Correlations between the expression of ICGs and the five genes included in the DRG prognostic model. (F) Correlations between the expression of ICGs and the DRG score. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.