Research Paper Volume 16, Issue 3 pp 2736—2752
circ_0039787 promotes cervical cancer cell tumorigenesis by regulation of the miR-877-5p-KRAS axis
Figure 4. Illustrating the negative regulation of miR-877-5p in CC cells by circ_0039787. (A) Database prediction of miRNAs potentially binding to circ_0039787. (B, C) Levels of candidate miRNAs following knockdown or overexpression of circ_0039787. (D) Prediction of binding between miR-877-5p and circ_0039787. (E, F) Luciferase reporter assay conducted for circ_0039787-WT and circ_0039787-MUT. (G) Levels of miR-877-5p in CC cell lines compared to control cell lines. (H) Levels of miR-877-5p in CC and paracancerous tissues (N = 56). (I) Correlations between the levels of circ_0039787 and miR-877-5p in CC tissue. P < 0.05, **P < 0.01, ***P < 0.001.