Figure 4 — Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation

Research Paper|Volume 16, Issue 2|pp. 1002–1020

Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation

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Figure 4.Epigenetic disorder is influenced by lifespan extending manipulations. The effect of caloric restriction in C57BL/6 mice on (A) epigenetic age predictions from each data type and (B) age-adjusted global disorder. The effect of caloric restriction in B6D2F1 mice on (C) epigenetic age predictions from each data type and (D) age-adjusted global disorder. Comparison of Snell dwarf and control mice on (E) epigenetic age predictions from each data type and (F) age-adjusted global disorder. The effect of growth hormone receptor knock-out (GHRKO) on (G) epigenetic age predictions from each data type and (H) age-adjusted global disorder. All plots show median, upper, and lower quartiles, and maximum and minimum. Outliers beyond 1.5 interquartile range are plotted.