Research Paper Volume 16, Issue 3 pp 2475—2493
KLF3 promotes colorectal cancer growth by activating WNT1
Figure 4. Down-regulation of KLF3 promotes CRC growth in vivo. (A–C) Representative images of HCT116-sh control or HCT116-sh-KLF3#1 subcutaneous xenograft tumor. Tumors in KLF3 knockdown mice grew faster than in controls in terms of volume and mass (N = 5/ group). (D) Ki67 level was elevated in HCT116-sh-KLF3#1 cell relative to HCT116-sh-NC cells. Scale bar: 20 μm. ***P< 0.001.