Research Paper Volume 16, Issue 3 pp 1983—2004
GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects
Figure 2. Survival of old 3xTg-AD mice after GV1001 treatment. (A) 1 mg/kg of GV1001 or an equivalent volume of 0.9% saline was subcutaneously injected into old-aged 3xTg-AD mice (n = 10 [male =5 and female 5]; control, n = 12 [male = 7 and female = 5]; 1 mg/kg of GV1001) from the age of 21 months until the mice were considered ready to sacrifice (endpoint). Injections were administered thrice a week until the endpoint. (B) Survival curves plotted using the Kaplan-Meier estimator. The survival of mice was markedly prolonged by administration of 1 mg/kg.