Research Paper Volume 16, Issue 2 pp 1829—1844
IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts
Figure 7. Schematic diagram illustrates the process whereby IL-17 treatment promotes IL-18 production in OASFs. IL-17 treatment upregulates levels of IL-18 expression in OASFs via MEK and ERK signaling and downregulates levels of miR-4492. IL-18 production elicits inflammatory responses during OA progression.