Research Paper Volume 16, Issue 2 pp 1829—1844
IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts
Figure 3. IL-17 promotes the production of IL-18 in OASFs. (A–D) OASFs were incubated with different concentrations of IL-17 (0–10 ng/mL) for 24 h. Levels of IL-18 expression were detected by qPCR (A), Western blot (B, C), and ELISA (D) analyses. (E, F) OASFs were transfected with IL-18 siRNA then incubated with IL-17 (10 ng/mL) for 24 h and assessed for IL-18 expression. Results are expressed as the means ± S.D. *p<0.05 compared with controls.