Research Paper Volume 16, Issue 2 pp 1829—1844

Figure 1. IL-18 is upregulated in clinical synovial tissue from OA patients. (A) Patterns of mRNA expression in the GEO dataset GSE890408 in synovial tissue samples from OA patients and normal healthy donors were used to analyze IL-18 expression. (B) Synovial tissues from the study cohorts of OA patients and normal healthy donors were subjected to H&E and IHC staining for detecting IL-18 expression. (C) Quantification of IHC results from Figure 1B. Results are expressed as the means ± S.D. *p<0.05 compared with healthy controls.