Figure 4. Screening the CRGs-related biomarkers based on the machine learning algorithm. (A) RF algorithm shows the importance of CRGs, which the cutoff of importance is set at 1. (B) The coefficients and log lambda value distribution of CRGs based on LASSO model. (C) Identification of CRGs- related biomarkers based on the LASSO and RF algorithms. (D) Correlation analysis between GDF15, IGHM and IGLC1.