Research Paper Volume 16, Issue 2 pp 1374—1389
Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis
Figure 2. Exercise attenuated the oxidative damage in the livers of the AD mice. (A) Protein carbonyl contents in the livers (n = 6 per group). (B) MDA contents in the livers (n = 6 per group). (C) Relative expression of p47 phox mRNA in the livers (n = 6 per group). (D) Relative expression of NOX4 mRNA in the livers (n = 6 per group). (E) CD68 and p47 phox immunofluorescence staining representative images of the livers (n = 4 per group). (F) Quantitative statistics of the mean fluorescence intensity of CD68. (G) Quantitative statistics of the mean fluorescence intensity of p47 phox. (H) Fluorescence intensity changes in CD68 and p47 phox in the WT group. (I) Fluorescence intensity changes in CD68 and p47 phox in the SE-AD group. (J) Fluorescence intensity changes in CD68 and p47 phox in the EX-AD group. The data are expressed as means ± SDs. # p < 0.05 and ## p < 0.01 compared with the WT group, and * p < 0.05 compared with the SE-AD group.