Research Paper Volume 16, Issue 2 pp 1374—1389
Treadmill exercise can regulate the redox balance in the livers of APP/PS1 mice and reduce LPS accumulation in their brains through the gut-liver-kupffer cell axis
Figure 1. AD mice with liver damage that was alleviated after exercise. (A) Weights of the mouse livers (n = 8 per group). (B) Ratios of the mouse livers to body weights (n = 8 per group). (C) Serum glutathione aminotransferase contents (n = 6 in each group). (D) Serum glutathione aminotransferase contents (n = 6 in each group). (E) Representative images of the liver HE staining, with the black arrows indicating the abnormally aggregated Kupffer cells (n = 4 in each group). (F) Representative images of the liver CD68 immunofluorescence staining, with the white arrows indicating the abnormally aggregated Kupffer cells (n = 4 in each group). The data are expressed as means ± SDs. ## p < 0.01 compared with the WT group and * p < 0.05 compared with the SE-AD group.