Figure 2. (A) Trabecular bone at distal femoral metaphysis observed by H&E staining. (B, C) Serum levels of bone turnover biomarkers including PINP and CTX-I. (D–G) Comparison of three-point bending test parameters including maximum displacement, fracture load, peak load, and stiffness. Data are means ± SEM. n = 6, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001; ns, no significance.