Research Paper Volume 15, Issue 24 pp 15489—15503

Figure 3. GO and KEGG pathway analyses of the genes associated with the differentially expressed eccDNAs. (A, B) Cluster and volcano plots show eccDNAs differentially expressed in the OP group. (C) GO enrichment analysis histogram (the abscissa is the secondary GO term, the ordinate is the number of the genes in this term, and the different tincts represents different types of GO terms). (D) KEGG pathway annotation: metabolism, genetic information processing, environmental information processing, cellular processes, organismal systems, human-diseases. (E–G) Top 20 cell components, top 20 molecular functions and top 20 biological processes. (H) KEGG enrichment bar chart (using the first 20 pathways with the smallest Q-value to draw this graph, the abscissa is the number of the designated pathway and is a percentage of all differential gene numbers).