Research Paper Volume 16, Issue 2 pp 1128—1144
An enriched environment ameliorates maternal sleep deprivation-induced cognitive impairment in aged mice by improving mitochondrial function via the Sirt1/PGC-1α pathway
Figure 6. The effect of EE on MSD-induced changes in hippocampal Iba-1, SYN, PSD-95, PGC-1α, and Sirt1 protein levels (n = 6). (A) The hippocampal expression levels of Iba-1, SYN, PSD-95, PGC-1α, and Sirt1 measured by western blotting. 1: males in the control (CON) group; 2: males in the MSD group; 3: males in the MSD+EE group; 4: females in the CON group; 5: females in the MSD group; 6: females in the MSD+EE group. (B–F) Protein quantification results. (B) Iba-1, (C) SYN, (D) PSD-95, (E) PGC-1α, and (F) Sirt1. **P < 0.01 vs. males in the CON group; ##P < 0.01 vs. males in the MSD group; $$P < 0.01 vs. females in the CON group; &P < 0.05 and &&P < 0.01 vs. females in the MSD group.