Figure 1. The effects of EE on MSD-induced changes in cognitive performance (n = 8). Escape latency, swim distance and velocity of control (CON) group (A–C), males (D–F), and females (G–I). (J) Percent time spent in the target quadrant. (K) Percent distance swam in the target quadrant. *P < 0.05 and ** P< 0.01 vs. male mice in the CON group; #P < 0.05 and ##P < 0.01 vs. male mice in the MSD group; $P < 0.05 and $$P < 0.01 vs. female mice in the CON group; &P < 0.05 and &&P < 0.01 vs. female mice in the MSD group.