Research Paper Volume 15, Issue 24 pp 15451—15472
Identification and validation of key biomarkers associated with macrophages in nonalcoholic fatty liver disease based on hdWGCNA and machine learning
Figure 3. Identification of the crucial modules related to NASH-macrophages by hdWGCNA. (A) The dot plot showing the comparison of outgoing and incoming signaling patterns. (B) Heatmap showing the relative importance of each cell group in the MIF signaling network. (C) Circle plot showing the communication strength between interacting cells in the MIF signaling network. (D) Bubble plot showing the significant ligand-receptor pairs between cells. (E) Six gene modules were obtained and the top ten hub genes were presented according to the hdWGCNA pipeline. (F) Module activities in different macrophage clusters. (G) Correlation analysis between different models. (H) UMAP plots illustrating the distribution of each module.