Research Paper Volume 15, Issue 24 pp 15324—15339

Figure 6. Recombinant NRG1 enhanced the levels of ErbB4, PV and MMP-9 in ALS mice. The expression of ErbB4, PV and MMP-9 were determined by immunofluorescence in control mice and mice treated with 0.5 mg/kg NRG1. The yellow boxes represent the typical positive cells (enlarged approximate twice on the original position). The typical PV, MMP-9 and ErBb4 positive cells are enlarged approximate 4 times and shown on the bottom right panel. Scale bar = 100 μM (A) and the quantified results (B) in mice at 130~140 days. ^***P < 0.001 vs. SOD1^G93A. ^###P < 0.001 vs. SOD1^G93A+PBS. In all experiments, half male and half female mice were used in each group (n = 6).