Research Paper

Figure 2. Effects of RAP1 on life and pathological score in colitis mice. (A) Dynamic weight monitoring (n= 10). DSS could induce weight loss in mice, while RAP1 could slow down such weight loss trend. (B) DAI scoring (n= 10). DSS mice exhibited increase in the DAI score. RAP1 mice displayed significantly lower DAI score than the DSS mice, albeit certain increase. (C) Intestinal length measurement (n= 10). Intestinal length was shortened in the DSS group, which was shorter than that in the RAP1 group. (D, E) Thymus and spleen indices (n= 10). DSS group exhibited lower thymus index and higher spleen index than the Control group. RAP1 could heighten the thymus index and lower the spleen index. (F) Pathological scoring (n= 10). Control mice scored 0, while significant score reduction was noted in the RAP1 group, showing lower value than the DSS group. *P< 0.05 vs. Control; #P< 0.05 vs. DSS.