Research Paper Volume 15, Issue 24 pp 15134—15160
Experimental validation and pan-cancer analysis identified COL10A1 as a novel oncogene and potential therapeutic target in prostate cancer
Figure 14. Knockdown of COL10A1 inhibits proliferation, migration, and invasion of prostate cancer cells. Western blotting analysis of the indicated proteins in PC-3 and C4-2 cells transfected with the indicated siRNA (A). CCK-8 assay was performed to detect the cell viability of PC-3 and C4-2 cells that knocked down for COL10A1 by siRNA (B). Colony formation assay was performed to detect the cell growth of PC-3 and C4-2 cells that knocked down for COL10A1 by siRNA (C). Transwell assays of PC-3 and C4-2 cells with knockdown of COL10A1 were showed the ability of migration and invasion (D, E).