Research Paper Volume 15, Issue 24 pp 14957—14984

A novel oxidative stress-related gene signature as an indicator of prognosis and immunotherapy responses in HNSCC

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Figure 1. Unsupervised clustering analysis for the head and neck squamous carcinoma samples based on the expression of oxidative stress-related genes. (A) Consensus matrices of the TCGA-HNSC cohort with k = 3; 1, 2 and 3 denote the three subgroups. (B) The CDF plot of unsupervised clustering analysis. (C) Relative change in area under CDF curve for k = 2–5. (D) OS survival curves of the three oxidative stress-related subgroups. (E) Visualization of the results of the PCA analysis for the oxidative stress-related genes. (F) Heat map of the expression of the oxidative stress-related genes in the three subgroups.