Research Paper Volume 15, Issue 18 pp 9661—9675

Aberrant expression of AKR1B1 indicates poor prognosis and promotes gastric cancer progression by regulating the AKT-mTOR pathway

class="figure-viewer-img"

Figure 1. AKR1B1 expression in GC and adjacent normal tissues. (A) The representative IHC images depicting in situ AKR1B1 expression in Case 1#, 2#, 3# GC and adjacent normal tissues (scale bar = 100 μm). (BE) The IHC scores of AKR1B1 in (B) GC vs. normal tissues, (C) Tumors with or without lymph node metastasis, and (D) TNM stage I–II vs. stage III. (E) The overall survival analysis of AKR1B1pos vs. AKR1B1neg GC patients. (F) In the subgroup of TNM staging I–II, the overall survival analysis of AKR1B1pos vs. AKR1B1neg GC patients. (G) The overall survival analysis of AKR1B1pos vs. AKR1B1neg GC patients in the subgroup of TNM staging III.