Research Paper Volume 15, Issue 18 pp 9614—9632
ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway
Figure 2. ALDOC controls proliferation, migration and apoptosis of NSCLC cells. (A, B) CCK8 assay (A) and colony formation assay (B) were performed to assess the alterations in cell proliferation upon knocking down ALDOC in A549 and NCI-H1299 cells. (C, D) After silencing ALDOC in A549 and NCI-H1299 cells, the abilities to migrate were analyzed through transwell chambers assay (C) and wound-healing assay (D). (E) After silencing ALDOC in A549 and NCI-H1299 cells, the changes in cell apoptosis were tested through flow cytometry detection. *** P < 0.001; **P < 0.01.