Research Paper Volume 15, Issue 18 pp 9590—9613
YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B
Figure 2. YY1 promotes cancer progression through autophagy enhancement. (A, B) The in vitro CCK-8 assay of AGS and MGC803 cells stably transfected with Ca-NC, Ca-YY1, Ci-NC or Ci-YY1 and those treated with DMSO, 3-MA (1.0 μM), PBS or ATP (0.1 mM). (C–F) Representative images (left) and the quantification (right) of colony formation (C, D) and transwell (E, F) assays showing the growth and migration of GC cells transfected with Ca-NC, Ca-YY1, Ci-NC or Ci-YY1 and those treated with 3-MA (1.0 μM) or ATP (0.1 mM). *P < 0.05 vs. Ca-NC+DMSO, Ci-NC+PBS.