Research Paper Volume 15, Issue 18 pp 9544—9560
Human umbilical cord mesenchymal stem cells-derived exosomes exert anti-inflammatory effects on osteoarthritis chondrocytes
Figure 6. Sequencing and bioinformatic analysis of mRNA in chondrocytes. (A) Volcano plot of genes differentially expressed by sequencing of chondrocytes from different groups. (B) Venn diagram of 1675 genes up-regulated in chondrocytes treated with IL-1β relative to normal chondrocyte, 275 genes downregulated in chondrocytes treated with IL-1β and hUC-MSCs-Exos relative to chondrocytes treated with IL-1β, and 3095 genes related to osteoarthritis in GeneCards database. (C) Heatmap of the screened 20 differentially expressed genes. (D–G) KEGG and GO (GO biological process, GO cellular component and GO molecular function) analysis of the screened 20 differentially expressed genes. The color of bars indicates p values, and p< 0.05 was considered significant.