Research Paper Volume 15, Issue 16 pp 8487—8500
ZBTB34 is a hepatocellular carcinoma-associated protein with a monopartite nuclear localization signal
Figure 7. The mechanism of ZBTB34 entering the nucleoplasm. ZBTB34 binds to importins α1, α3, and α4 in the cytoplasm via its NLS and then recruits importin β1 to form a complex. These complexes transport ZBTB34 into nucleoplasm and then the importins are disassembled upon interaction with RanGTP.