Research Paper Volume 15, Issue 16 pp 8458—8470
Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia
Figure 4. The effect of curcumin on learning and memory impairment in pT-ION mice. (A) Time to reach the hidden platform. (B) Total swimming distance during the trial. (C) Tracks of the mice in the probe test. (D) Number of times the mice crossed over the platform. (E) Spending time to target zone area. N = 8 mice/group. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. sham group; #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. pT-ION group, (A, B): two-way ANOVA and Tukey’s test, (C–E): one-way ANOVA and Tukey’s test.