Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia

Hong-Wei Zhi; Yu-Zhi Jia; Huai-Qian Bo; Hai-Tao Li; Si-Shuo Zhang; Ya-Han Wang; Jie Yang; Ming-Zhe Hu; Hong-Yun Wu; Wen-Qiang Cui; Xiang-Dong Xu

doi:doi:10.18632/aging.204984

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Research Paper Volume 15, Issue 16 pp 8458—8470

Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia

Figure 3. The effect of curcumin on orofacial allodynia induced by pT-ION. (A) The primary mechanical hyperalgesia in area V2. (B) The secondary mechanical hyperalgesia in area V3. (C) The secondary cold allodynia in area V3. N = 8 mice/group. ^*P < 0.05 and ^***P < 0.001 vs. sham group; ^###P < 0.001 vs. pT-ION group, one-way ANOVA and Tukey’s test.