Research Paper Volume 15, Issue 16 pp 8458—8470
Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia
Figure 2. The learning and memory impairment induced pT-ION mice. The training trials were performed for 4 consecutive days (days 24, 25, 26, and 27 after pT-ION). The probe test was performed after the training (day 28 after pT-ION). (A) Time to reach the hidden platform. (B) Total swimming distance during the trial. (C) Tracks of the mice in the probe test on the fifth day. (D) Number of times the mice crossed over the platform. (E) Spending time to target zone area. N = 8 mice/group. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. naive group, (A, B): two-way ANOVA and Tukey’s test, (C–E): one-way ANOVA and Dunnett test.