Research Paper Volume 15, Issue 16 pp 8458—8470
Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia
Figure 1. The time course of pT-ION induced orofacial allodynia. (A) The schematic diagram of orofacial branch of the trigeminal nerve and pT-ION surgery. (B) and (C) showed the primary and secondary mechanical hyperalgesia induced by pT-ION in the ipsilateral facial V2 and V3 area, respectively. (D) showed the secondary cold allodynia in the ipsilateral facial V3 area. N = 8 mice/group. ***P < 0.001 vs. naive group, two-way ANOVA and Tukey’s test.