Research Paper Volume 15, Issue 16 pp 8433—8443
Catapol reduced the cognitive and mood dysfunctions in post-stroke depression mice via promoting PI3K-mediated adult neurogenesis
Figure 4. PI3K signaling plays the key roles in catapol mediated neurogenesis and behavioral effects in PSD. (A) Confocal image to show the primary neuron induction profile under hypoxia and DEX treatment. NeuN was for neural nuclear labelling and MAP2 was used for fiber labelling. (B, C) Statistical analysis of the NeuN+ and MAP2+ neural density under different treatment. One-way ANOVA, post-hoc, *: p<0.05, **: p<0.01. (D) Timeline to show the treatment of LY294002 before and after the MCAO model. (E, F) Statistical analysis to show the immobility time in FST during the LY294002 pre- or post-MCAO administration. One-way ANOVA, post-hoc, **: p<0.01, ***: p<0.001.