Research Paper Volume 15, Issue 16 pp 8298—8314

Figure 2. The transcriptomic profile of Gastrodin intervention on the hippocampus of diabetic rats and further confirmation. (A) Differentially expressed genes among NC9w, DM9w+S, DM9w+G60 and DM9w+G120 group. (B) Volcano plot of all genes based on their log2 fold-change and adjusted P-values between NC9w and DM9w+S group. Differentially expressed genes were classified at an adjusted P-value of < 0.05. (C) The KEGG pathways enriched between NC9w and DM9w+S group. The rich factor refers to the ratio of the number of DEGs to the number of total annotated genes in a certain pathway. (D–H) qPCR analysis of the mRNA expression of PAK2 (D) Mrpl1 (E) Sp8 (F) RagA (G) and RagB (H) in the hippocampus of the NC9w, DM9w+S, DM9w+G60 and DM9w+G120 groups. *p < 0.05 and **p < 0.01.