Research Paper Volume 15, Issue 15 pp 7362—7380
Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice
Figure 5. IPA’s predictive downstream effect and upstream regulator analytics between Ovx/Sham and OA/YA. Phosphopeptides identified in both the Ovx/Sham and OA/YA datasets were submitted to IPA for comparative analysis. (A) canonical pathways, (B) functions, and (C) kinases and phosphatases using IPA’s predictive activation Z-score to determine downstream and upstream effects of estrogen deficiency. Pathways, functions, and kinases identified in both datasets are represented. Significant Z-scores were accepted at |Z| ≥ 2. Red box denotes significant Z-scores.