Figure 5.IPA’s predictive downstream effect and upstream regulator analytics between Ovx/Sham and OA/YA. Phosphopeptides identified in both the Ovx/Sham and OA/YA datasets were submitted to IPA for comparative analysis. (A) canonical pathways, (B) functions, and (C) kinases and phosphatases using IPA’s predictive activation Z-score to determine downstream and upstream effects of estrogen deficiency. Pathways, functions, and kinases identified in both datasets are represented. Significant Z-scores were accepted at |Z| ≥ 2. Red box denotes significant Z-scores.
