Figure 3. Comparative GO term enrichment analysis between Ovx/Sham and OA/YA. Phosphopeptides were mapped back to their precursor protein and submitted for Gene Ontology (GO) overrepresentation analysis using the clusterProfiler package in R. The top 10 overrepresented GO terms in the dataset for (A) molecular functions, (B) cellular components, and (C) biological processes are listed. P-value was adjusted using Benjamini – Hochberg post-hoc analysis for multiple comparison. Significant GO terms were accepted at p.adjusted < 0.05.