Research Paper Volume 15, Issue 18 pp 9377—9390
Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B
Figure 3. Ar-turmerone induced glioma cell cycle arrest at G1/S phase in vitro. (A) Gene Ontology analysis was performed to determine the enriched pathways of differentially expressed genes in ar-turmerone−treated glioma cells. (B) KEGG analysis was performed to determine the enriched pathways of differentially expressed genes in ar-turmerone−treated glioma cells. (C) Gene enrichment plots depict a series of genes enriched in the Cell cycle. (D) Glioma cells were treated with or the control, and flow cytometry was used to detect the cell cycle distribution in each group. (E) Western blotting was used to detect the expression of CDK2, P27 and CyclinD1 in glioma cells treated with ar-turmerone (200 μM) or the control. *P < 0.05.