Figure 4 — Causal pathway from telomere length to occurrence and 28-day mortality of sepsis: an observational and mendelian randomization study

Research Paper|Volume 15, Issue 15|pp. 7727–7740

Causal pathway from telomere length to occurrence and 28-day mortality of sepsis: an observational and mendelian randomization study

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Figure 4.MR leave-one-out sensitivity analysis. Leave-one-out analysis is used to evaluate whether any SNP is driving the causal effect. (A) Represents the results of MR leave−one−out sensitivity analysis for “Sepsis” on “LTL”. (B) Reflects the findings of MR leave−one−out sensitivity analysis for “LTL” on “Sepsis”, which change dramatically when SNPs marked in red are removed. (C) Contains the results of MR leave−one−out sensitivity analysis for “LTL” on “Sepsis (28-day death)”. Abbreviations: LTL: leukocyte telomere length; MR: Mendelian randomization; SNPs: single-nucleotide polymorphisms.