Research Paper Volume 15, Issue 15 pp 7709—7726

Figure 6. STAT3 inhibition facilitated neurological recovery after ICH. (A, B) Summarized results showing neurological assessment (mNSS score, corner-turning test) of MK-8931- or niclosamide-treated groups of mice at 1 and 3 days post-ICH. n = 8 per group. (C) Brain water content in groups of mice receiving the indicated treatments at Day 1 after ICH. n = 11 per group. (D, E) Analysis of the gene expression of inflammatory cytokines in sorted ICH 3-day microglia under the indicated treatment, n = 5 per group. Data are shown as the relative change compared to the sham group. (F) Flow cytometry histogram of in vivo RBC engulfment in microglia/macrophages. (G) Quantification of microglial phagocytosis in the indicated treated mice at Day 3 after ICH. n = 5 per group. All data are presented as the mean ± SD. ^*P < 0.05, ^**P < 0.01.