Research Paper Volume 15, Issue 15 pp 7673—7688
Emodin attenuates diabetic kidney disease by inhibiting ferroptosis via upregulating Nrf2 expression
Figure 5. Emodin inhibited the deletion of Nrf2 induced ferroptosis. The expression level as well as semi-quantitative analysis of Nrf2 protein (A, B). The mRNA expression of Nrf2 (C). The expression levels as well as semi-quantitative analysis of ferroptosis indicators were measured in Si-Nrf2 cells with or without treatment (D, E). The changes in concentrations of iron and MDA were calculated (F, G). *P < 0.05, **P < 0.01 vs. Si-Nrf2 group, #P < 0.05, ##P < 0.01 vs. DM group.